Polymorphisms in the folate-metabolizing genes MTR, MTRR, and CBS and breast cancer risk

Weiner, Alexandra S.; Boyarskikh, Uljana A.; Voronina, Elena N.; Selezneva, Inna A.; Sinkina, Tatiana V.; Lazarev, Alexandr F.; Petrova, Valentina D.; Filipenko, Maxim L.

doi:10.1016/j.canep.2011.11.010

« Previous Next »Cancer Epidemiology
Volume 36, Issue 2 , Pages e95-e100, April 2012

Polymorphisms in the folate-metabolizing genes MTR, MTRR, and CBS and breast cancer risk

Alexandra S. Weiner
- Institute of Chemical Biology and Fundamental Medicine, Group of Pharmacogenomics, Lavrentjeva, 8, 630090 Novosibirsk, Russia
- Novosibirsk State University, Department of Molecular Biology, Pirogova, 2, 630090 Novosibirsk, Russia
Uljana A. Boyarskikh
- Institute of Chemical Biology and Fundamental Medicine, Group of Pharmacogenomics, Lavrentjeva, 8, 630090 Novosibirsk, Russia
Elena N. Voronina
- Institute of Chemical Biology and Fundamental Medicine, Group of Pharmacogenomics, Lavrentjeva, 8, 630090 Novosibirsk, Russia
Inna A. Selezneva
- Altai Branch of the Russian Blokhin Cancer Research Centre, Nikitina, 77, 656049 Barnaul, Russia
Tatiana V. Sinkina
- Altai Branch of the Russian Blokhin Cancer Research Centre, Nikitina, 77, 656049 Barnaul, Russia
Alexandr F. Lazarev
- Altai Branch of the Russian Blokhin Cancer Research Centre, Nikitina, 77, 656049 Barnaul, Russia
Valentina D. Petrova
- Altai Branch of the Russian Blokhin Cancer Research Centre, Nikitina, 77, 656049 Barnaul, Russia
Maxim L. Filipenko
- Institute of Chemical Biology and Fundamental Medicine, Group of Pharmacogenomics, Lavrentjeva, 8, 630090 Novosibirsk, Russia
- Corresponding author. Tel.: +7 383 3635171; fax: +7 383 3635117.

Received 29 August 2011; received in revised form 28 November 2011; accepted 30 November 2011. published online 19 December 2011.

Abstract

Alterations in the nucleotide sequences of folate-metabolizing genes can increase the risk of malignant transformation. The aim of our study was to investigate the association of three single-nucleotide polymorphisms (SNPs) in the folate-metabolizing genes – A2756G MTR, A66G MTRR, and 844ins68 CBS – which have putative functional significance in breast cancer risk. The allele and genotype frequencies of the SNPs were determined in a case group (840 women with sporadic breast cancer) and a control group (770 women). No statistically significant association of studied SNPs with breast cancer was revealed. A meta-analysis, which included data obtained from the literature and the present research, did not reveal any statistically significant associations of these SNPs with breast cancer. The results obtained provide evidence that these SNPs are not involved in the development of breast cancer.

Keywords: Breast cancer, Folate-metabolizing genes, Meta-analysis, Polymorphism, SNP