Risk factor for clear cell renal cell carcinoma in Chinese population: A case–control study

Wang, Guoping; Hou, Jianguo; Ma, Liye; Xie, Jiaxin; Yin, Jianhua; Xu, Danfeng; Chang, Wenjun; Tan, Xiaojie; Su, Tong; Zhang, Hongwei; Cao, Guangwen

doi:10.1016/j.canep.2011.09.006

« Previous Next »Cancer Epidemiology
Volume 36, Issue 2 , Pages 177-182, April 2012

Risk factor for clear cell renal cell carcinoma in Chinese population: A case–control study

Guoping Wang
- Department of Epidemiology, Second Military Medical University, Shanghai, China
- These authors contributed equally to this work.
Jianguo Hou
- Department of Urology, the 1st Affiliated Hospital, Second Military Medical University, Shanghai, China
- These authors contributed equally to this work.
Liye Ma
- Department of General Surgery, the 1st Affiliated Hospital, Second Military Medical University, Shanghai, China
- These authors contributed equally to this work.
Jiaxin Xie
- Department of Epidemiology, Second Military Medical University, Shanghai, China
Jianhua Yin
- Department of Epidemiology, Second Military Medical University, Shanghai, China
Danfeng Xu
- Department of Urology, the 2nd Affiliated Hospital, Second Military Medical University, Shanghai, China
Wenjun Chang
- Department of Epidemiology, Second Military Medical University, Shanghai, China
Xiaojie Tan
- Department of Epidemiology, Second Military Medical University, Shanghai, China
Tong Su
- Department of Epidemiology, Second Military Medical University, Shanghai, China
Hongwei Zhang
- Department of Epidemiology, Second Military Medical University, Shanghai, China
Guangwen Cao
- Department of Epidemiology, Second Military Medical University, Shanghai, China
- Corresponding author. Tel.: +86 21 81871060; fax: +86 21 81871060.

Received 18 January 2011; received in revised form 19 September 2011; accepted 20 September 2011. published online 05 October 2011.

Abstract

Background: Risk factors for clear cell renal cell carcinoma (ccRCC) differ among populations and remain controversial. We carried out a hospital-based case–control study to examine the effects of health status, lifestyle, and some genetic polymorphisms on ccRCC risk in Chinese subjects. Methods: Between 2007 and 2009, 250 newly diagnosed, histologically confirmed ccRCC cases and 299 sex-, age-matched healthy controls provided complete information including consumption of tea and alcohol, smoking, occupational exposure, body mass index (BMI), hypertension, diabetes, and urolithiasis by face-to-face interview in Shanghai. Genetic polymorphisms of cytochrome P450 mono-oxygenase (CYP1A1: 6235T>C, 4889A>G, and 4887C>A), glutathione S-transferase (GSTP1: 342A>G), and N-acetyltransferase (NAT2: 481C>T, 590G>A, and 857G>A) were identified by PCR-RFLP and DNA sequencing. Adjusted odds ratio (AOR) and 95% confidence interval (CI) were derived through multivariate logistic regression. Results: Green tea intake (≥500ml/d) was inversely associated with ccRCC risk, with an AOR of 0.34 (95% CI 0.21–0.55). BMI (≥25kg/m²), hypertension, and urolithiasis were independently associated with an increased risk of ccRCC, with AOR (95% CI) of 2.10 (1.32–3.34), 2.49 (1.57–3.93), and 3.33 (1.12–9.89), respectively. No association was observed between smoking, alcohol consumption, or occupational exposure with ccRCC risk. The polymorphisms and their interactions with the environmental exposures were mostly not associated with ccRCC risk. Conclusion: BMI (≥25kg/m²), hypertension, and urolithiasis are independently associated with an increased risk, whereas green tea intake (≥500ml/d) is independently associated with a decreased risk of ccRCC. The polymorphisms of the xenobiotic-metabolizing enzymes are weakly associated with ccRCC risk in Chinese subjects.