Cancer Epidemiology
Volume 34, Issue 4 , Pages 442-447 , August 2010

Identification of novel large genomic rearrangements at the BRCA1 locus in Malaysian women with breast cancer

  • Noor Akmal Sharifah

      Affiliations

    • Department of Pathology, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia
    • Corresponding Author InformationCorresponding author. Tel.: +60 3 9145 5372; fax: +60 3 9173 7340.
    • ,
  • Md Isa Nurismah

      Affiliations

    • Department of Pathology, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia
    • ,
  • Han Chung Lee

      Affiliations

    • Department of Pathology, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia
    • ,
  • Aziz Nur Aisyah

      Affiliations

    • Department of Pathology, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia
    • ,
  • Ching Huat Clarence-Ko

      Affiliations

    • Department of Pathology, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia
    • ,
  • Ismail Naqiyah

      Affiliations

    • Department of Surgery, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia
    • ,
  • Mohamad Rohaizak

      Affiliations

    • Department of Surgery, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia
    • ,
  • Ismail Fuad

      Affiliations

    • Department of Radiotherapy and Oncology, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia
    • ,
  • A. Rahman A. Jamal

      Affiliations

    • UKM Medical Molecular Biology Institute, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia
    • ,
  • Abdul Latiff Zarina

      Affiliations

    • UKM Medical Molecular Biology Institute, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia
    • ,
  • Emran Nor Aina

      Affiliations

    • Department of General Surgery, Hospital Kuala Lumpur, 50586 Jalan Pahang, Wilayah Persekutuan, Kuala Lumpur, Malaysia
    • ,
  • Kitan Normayah

      Affiliations

    • Department of Surgery, Putrajaya Hospital, Federal Government Administration Centre, Precint 7, 62250, Malaysia
    • ,
  • Abdullah Nor Hisham

      Affiliations

    • Department of Surgery, Putrajaya Hospital, Federal Government Administration Centre, Precint 7, 62250, Malaysia

,Accepted 12 April 2010.

References 

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  2. Wooster R, Bignell G, Lancaster J, Swift S, Seal S, Mangion J, et al. Identification of the breast cancer susceptibility gene BRCA2. Nature. 1995;378:789–792
  3. Ford D, Easton DF, Stratton M, Narod S, Goldgar D, Devilee P, et al. Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. Am J Hum Genet. 1998;62:676–689
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  15. Introduction to quantitative PCR: methods & applications guide. Stratagene; 2007;pp. 37–43
  16. Sharifah NA, Nurismah MI, Lee HC, Clarence-Ko CH, Naqiyah I, Rohaizak M, et al. Denaturing high performance liquid chromatography (DHPLC) in the screening of BRCA1 and BRCA2 mutations in breast cancer. In: Proceedings of the 8th Malaysia Genetic Congress. August 4–6, Genting, Malaysia. 2009;
  17. Lim YK, Lau PTC, Ali AB, Lee SC, Wong JE-L, Putti TC, et al. Identification of novel BRCA large genomic rearrangements in Singapore Asian breast and ovarian patients with cancer. Clin Genet. 2007;71:331–342
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  24. Armaoua S, Konstantopouloub I, Anagnostopoulosa T, Razisc E, Boukovinasd L, Xenidisd N, et al. Novel genomic rearrangements in the BRCA1 gene detected in Greek breast/ovarian cancer patients. Eur J Cancer. 2007;43:443–453
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PII: S1877-7821(10)00072-X

doi: 10.1016/j.canep.2010.04.010

Cancer Epidemiology
Volume 34, Issue 4 , Pages 442-447 , August 2010

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