Cancer Epidemiology
Volume 34, Issue 3 , Pages 279-284 , June 2010

Relationship between serum levels of insulin-like growth factors and subsequent risk of cancer mortality: Findings from a nested case–control study within the Japan Collaborative Cohort Study

  • Truong-Minh Pham

      Affiliations

    • Department of Preventive Medicine and Community Health, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu-shi 807-8555, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 93 691 7244; fax: +81 93 603 4307.
    • ,
  • Yoshihisa Fujino

      Affiliations

    • Department of Preventive Medicine and Community Health, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu-shi 807-8555, Japan
    • ,
  • Kei Nakachi

      Affiliations

    • Department of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima, Japan
    • ,
  • Koji Suzuki

      Affiliations

    • Department of Public Health, Fujita Health University School of Health Sciences, Toyoake, Japan
    • ,
  • Yoshinori Ito

      Affiliations

    • Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University, Graduate School of Medicine, Nagoya, Japan
    • ,
  • Yoshiyuki Watanabe

      Affiliations

    • Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Sciences, Kyoto, Japan
    • ,
  • Yutaka Inaba

      Affiliations

    • Division of Public Health, Department of Food and Health Sciences, Faculty of Human Life Sciences, Jissen Women's University, Hino, Japan
    • ,
  • Kazuo Tajima

      Affiliations

    • Aichi Cancer Center Research Institute, Nagoya, Japan
    • ,
  • Akiko Tamakoshi

      Affiliations

    • Department of Public Health, Aichi Medical University School of Medicine, Aichi, Japan
    • ,
  • Takesumi Yoshimura

      Affiliations

    • Fukuoka Institute of Health and Environmental Sciences, Fukuoka, Japan
    • ,
  • for the JACC Study Group

      Affiliations

    • See Acknowledgements for the investigators (name and affiliation) involved in the JACC Study.

,Accepted 27 March 2010.

References 

  1. Pollak MN, Schernhammer ES, Hankinson SE. Insulin-like growth factors and neoplasia. Nat Rev Cancer. 2004;4:505–518
  2. Samani AA, Yakar S, LeRoith D, Brodt P. The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev. 2007;28:20–47
  3. Khandwala HM, McCutcheon IE, Flyvbjerg A, Friend KE. The effects of insulin-like growth factors on tumorigenesis and neoplastic growth. Endocr Rev. 2000;21:215–244
  4. Sara VR, Hall K. Insulin-like growth factors and their binding proteins. Physiol Rev. 1990;70:591–614
  5. Firth SM, Baxter RC. Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev. 2002;23:824–854
  6. Laughlin GA, Barrett-Connor E, Criqui MH, Kritz-Silverstein D. The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-binding protein-1 levels with all cause and cardiovascular disease mortality in older adults: the Rancho Bernardo Study. J Clin Endocrinol Metab. 2004;89:114–120
  7. Brugts MP, van den Beld AW, Hofland LJ, van der Wansem K, van Koetsveld PM, Frystyk J, et al. Low circulating insulin-like growth factor I bioactivity in elderly men is associated with increased mortality. J Clin Endocrinol Metab. 2008;93:2515–2522
  8. Yu H, Rohan T. Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst. 2000;92:1472–1489
  9. Renehan AG, Zwahlen M, Minder C, O’Dwyer ST, Shalet SM, Egger M. Insulin-like growth factor (IGF)-I, IGF binding protein-3, and cancer risk: systematic review and meta-regression analysis. Lancet. 2004;363:1346–1353
  10. Nomura AM, Stemmermann GN, Lee J, Pollak MN. Serum insulin-like growth factor I and subsequent risk of colorectal cancer among Japanese-American men. Am J Epidemiol. 2003;158:424–431
  11. Yu H, Jin F, Shu XO, Li BD, Dai Q, Cheng JR, et al. Insulin-like growth factors and breast cancer risk in Chinese women. Cancer Epidemiol Biomarkers Prev. 2002;11:705–712
  12. Allen NE, Roddam AW, Allen DS, Fentiman IS, Dos Santos Silva I, Peto J, et al. A prospective study of serum insulin-like growth factor-I (IGF-I), IGF-II, IGF-binding protein-3 and breast cancer risk. Br J Cancer. 2005;92:1283–1287
  13. Rollison DE, Giuliano AR, Risendal BC, Sweeney C, Boulware D, Laronga C, et al. Serum insulin-like growth factor (IGF)-1 and IGF binding protein-3 in relation to breast cancer among Hispanic and white, non-Hispanic women in the US Southwest. Breast Cancer Res Treat. 2009;(in press)
  14. Harman SM, Metter EJ, Blackman MR, Landis PK, Carter HB. Serum levels of insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-3, and prostate-specific antigen as predictors of clinical prostate cancer. J Clin Endocrinol Metab. 2000;85:4258–4265
  15. Stattin P, Rinaldi S, Biessy C, Stenman UH, Hallmans G, Kaaks R. High levels of circulating insulin-like growth factor-I increase prostate cancer risk: a prospective study in a population-based nonscreened cohort. J Clin Oncol. 2004;22:3104–3112
  16. London SJ, Yuan JM, Travlos GS, Gao YT, Wilson RE, Ross RK, et al. Insulin-like growth factor I, IGF-binding protein 3, and lung cancer risk in a prospective study of men in China. J Natl Cancer Inst. 2002;94:749–754
  17. Wakai K, Ito Y, Suzuki K, Tamakoshi A, Seki N, Ando M, et al. Serum insulin-like growth factors, insulin-like growth factor-binding protein-3, and risk of lung cancer death: a case–control study nested in the Japan Collaborative Cohort (JACC) Study. Jpn J Cancer Res. 2002;93:1279–1286
  18. Lin Y, Tamakoshi A, Kikuchi S, Yagyu K, Obata Y, Ishibashi T, et al. Serum insulin-like growth factor-I, insulin-like growth factor binding protein-3, and the risk of pancreatic cancer death. Int J Cancer. 2004;110:584–588
  19. Pham TM, Fujino Y, Kikuchi S, Tamakoshi A, Yatsuya H, Matsuda S, et al. A nested case–control study of stomach cancer and serum insulin-like growth factor (IGF)-1, IGF-2 and IGF-binding protein (IGFBP)-3. Eur J Cancer. 2007;43:1611–1616
  20. Tamakoshi A, Yoshimura T, Inaba Y, Ito Y, Watanabe Y, Fukuda K, et al. Profile of the JACC study. J Epidemiol. 2005;15(Suppl 1):S4–S8
  21. Ohno Y, Tamakoshi A. Japan collaborative cohort study for evaluation of cancer risk sponsored by monbusho (JACC study). J Epidemiol. 2001;11:144–150
  22. StataCorp . Stata Statistical Sofware: Release 9. College Station, TX: StataCorp LP; 2005;
  23. Saydah S, Graubard B, Ballard-Barbash R, Berrigan D. Insulin-like growth factors and subsequent risk of mortality in the United States. Am J Epidemiol. 2007;166:518–526
  24. Friedrich N, Haring R, Nauck M, Ludemann J, Rosskopf D, Spilcke-Liss E, et al. Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations. J Clin Endocrinol Metab. 2009;94:1732–1739
  25. Ma J, Pollak MN, Giovannucci E, Chan JM, Tao Y, Hennekens CH, et al. Prospective study of colorectal cancer risk in men and plasma levels of insulin-like growth factor (IGF)-I and IGF-binding protein-3. J Natl Cancer Inst. 1999;91:620–625
  26. Sugumar A, Liu YC, Xia Q, Koh YS, Matsuo K. Insulin-like growth factor (IGF)-I and IGF-binding protein 3 and the risk of premenopausal breast cancer: a meta-analysis of literature. Int J Cancer. 2004;111:293–297
  27. Hunt KJ, Toniolo P, Akhmedkhanov A, Lukanova A, Dechaud H, Rinaldi S, et al. Insulin-like growth factor II and colorectal cancer risk in women. Cancer Epidemiol Biomarkers Prev. 2002;11:901–905
  28. Lacey JV, Potischman N, Madigan MP, Berman ML, Mortel R, Twiggs LB, et al. Insulin-like growth factors, insulin-like growth factor-binding proteins, and endometrial cancer in postmenopausal women: results from a U.S. case–control study. Cancer Epidemiol Biomarkers Prev. 2004;13:607–612
  29. Rinaldi S, Toniolo P, Muti P, Lundin E, Zeleniuch-Jacquotte A, Arslan A, et al. IGF-I, IGFBP-3 and breast cancer in young women: a pooled re-analysis of three prospective studies. Eur J Cancer Prev. 2005;14:493–496

PII: S1877-7821(10)00057-3

doi: 10.1016/j.canep.2010.03.017

Cancer Epidemiology
Volume 34, Issue 3 , Pages 279-284 , June 2010

Article Tools