Cancer Epidemiology
Volume 34, Issue 4 , Pages 388-399 , August 2010

Occupational exposure to hexavalent chromium and cancers of the gastrointestinal tract: A meta-analysis

  • Nicole M. Gatto

      Affiliations

    • ToxStrategies, Inc., Rancho Santa Margarita, CA, United States
    • ,
  • Michael A. Kelsh

      Affiliations

    • Exponent, Inc., Menlo Park, CA, United States
    • ,
  • Diem Ha Mai

      Affiliations

    • Exponent, Inc., Irvine, CA, United States
    • ,
  • Mina Suh

      Affiliations

    • Exponent, Inc., Irvine, CA, United States
    • ,
  • Deborah M. Proctor

      Affiliations

    • ToxStrategies, Inc., Rancho Santa Margarita, CA, United States
    • Corresponding Author InformationCorresponding author at: ToxStrategies, Inc., 30021 Tomas St., Suite 300, Rancho Santa Margarita, CA 92688, United States. Tel.: +1 949 459 2140; fax: +1 949 459 2142.

,Accepted 23 March 2010.

References 

  1. Barceloux DG. Chromium. J Toxicol Clin Toxicol. 1999;37(2):173–194
  2. IARC. Monographs on the evaluation of carcinogenic risks to humans: chromium, nickel and welding. World Health Organization, International Agency for Research on Cancer; 1990.
  3. OSHA . Occupational exposure to hexavalent chromium; final rule. US Department of Labor; 2006;
  4. Proctor DM, Otani JM, Finley BL, Paustenbach DJ, Bland JA, Speizer N, et al. Is hexavalent chromium carcinogenic via ingestion? A weight-of-evidence review. J Toxicol Environ Health A. 2002;65(10):701–746
  5. US Environmental Protection Agency . Toxicological Review of Hexavalent Chromium. Washington, DC: National Center for Environmental Assessment, Office of Research and Development; 1998;
  6. Stout MD, Nyska A, Collins BJ, Witt KL, Kissling GE, Malarkey DE, et al. Chronic toxicity and carcinogenicity studies of chromium picolinate monohydrate administered in feed to F344/N rats and B6C3F1 mice for 2 years. Food Chem Toxicol. 2009;47(4):729–733
  7. Lucas JB, Kramkowski RS. Health hazard evaluation determination report number 74-87-221. Cincinnati, OH: US Department of Health Education and Welfare Center for Disease Control National Institute for Occupational Safety and Health; 1975.
  8. Mancuso TF, Hueper WC. Occupational cancer and other health hazards in a chromate plant: a medical appraisal. II. Clinical and toxicologic aspects. Ind Med Surg. 1951;20(8):393–407
  9. Beaumont JJ, Sedman RM, Reynolds SD, Sherman CD, Li LH, Howd RA, et al. Cancer mortality in a Chinese population exposed to hexavalent chromium in drinking water. Epidemiology. 2008;19(1):12–23
  10. Kerger BD, Butler WJ, Paustenbach DJ, Zhang J, Li S. Cancer mortality in chinese populations surrounding an alloy plant with chromium smelting operations. J Toxicol Environ Health A. 2009;72(5):329–344
  11. Becker N. Cancer mortality among arc welders exposed to fumes containing chromium and nickel. Results of a third follow-up: 1989–1995. J Occup Environ Med. 1999;41(4):294–303
  12. Gibb HJ, Lees PS, Pinsky PF, Rooney BC. Lung cancer among workers in chromium chemical production. Am J Ind Med. 2000;38(5):606
  13. Luippold RS, Mundt KA, Austin RP, Liebig E, Panko J, Crump C, et al. Lung cancer mortality among chromate production workers. Occup Environ Med. 2003;60(6):451–457
  14. Pokrovskaia LV, Shabynina NK. Carcinogenic hazards in the manufacture of chromium ferroalloys. Gig Tr Prof Zabol. 1973;17(10):23–26
  15. Costantini AS, Paci E, Miligi L, Buiatti E, Martelli C, Lenzi S. Cancer mortality among workers in the Tuscan tanning industry. Br J Ind Med. 1989;46(6):384–388
  16. Rafnsson V, Gunnarsdottir H, Kiilunen M. Risk of lung cancer among masons in Iceland. Occup Environ Med. 1997;54(3):184–188
  17. Axelsson G, Rylander R, Schmidt A. Mortality and incidence of tumours among ferrochromium workers. Br J Ind Med. 1980;37(2):121–127
  18. Deschamps F, Moulin JJ, Wild P, Labriffe H, Haguenoer JM. Mortality study among workers producing chromate pigments in France. Int Arch Occup Environ Health. 1995;67(3):147–152
  19. Birk T, Mundt KA, Dell LD, Luippold RS, Miksche L, Steinmann-Steiner-Haldenstaett W, et al. Lung cancer mortality in the German chromate industry, 1958 to 1998. J Occup Environ Med. 2006;48(4):426–433
  20. Korallus U, Ulm K, Steinmann-Steiner-Haldenstaett W. Bronchial carcinoma mortality in the German chromate-producing industry: the effects of process modification. Int Arch Occup Environ Health. 1993;65(3):171–178
  21. Blair A, Burg J, Foran J, Gibb H, Greenland S, Morris R, et al. Guidelines for application of meta-analysis in environmental epidemiology. ISLI Risk Science Institute. Regul Toxicol Pharmacol. 1995;22(2):189–197
  22. Andersson T, Ahlbom A. Episheet software: spreadsheets for the analysis of epidemiologic data. 2004;Available at: http://members.aol.com/krothman/episheet.xls
  23. Boice JD, Marano DE, Fryzek JP, Sadler CJ, McLaughlin JK. Mortality among aircraft manufacturing workers. Occup Environ Med. 1999;56(9):581–597
  24. Dalager NA, Mason TJ, Fraumeni JF, Hoover R, Payne WW. Cancer mortality among workers exposed to zinc chromate paints. J Occup Med. 1980;22(1):25–29
  25. Blair A. Mortality among workers in the metal polishing and plating industry, 1951–1969. J Occup Med. 1980;22(3):158–162
  26. Davies JM, Easton DF, Bidstrup PL. Mortality from respiratory cancer and other causes in United Kingdom chromate production workers. Br J Ind Med. 1991;48(5):299–313
  27. Moulin JJ, Portefaix P, Wild P, Mur JM, Smagghe G, Mantout B. Mortality study among workers producing ferroalloys and stainless steel in France. Br J Ind Med. 1990;47(8):537–543
  28. Rosenman KD, Stanbury M. Risk of lung cancer among former chromium smelter workers. Am J Ind Med. 1996;29(5):491–500
  29. Guberan E, Usel M, Raymond L, Tissot R, Sweetnam PM. Disability, mortality, and incidence of cancer among Geneva painters and electricians: a historical prospective study. Br J Ind Med. 1989;46(1):16–23
  30. Kano K, Horikawa M, Utsunomiya T, Tati M, Satoh K, Yamaguchi S. Lung cancer mortality among a cohort of male chromate pigment workers in Japan. Int J Epidemiol. 1993;22(1):16–22
  31. Franchini I, Magnani F, Mutti A. Mortality experience among chromeplating workers. Initial findings. Scand J Work Environ Health. 1983;9(3):247–252
  32. Sorahan T, Faux AM, Cooke MA. Mortality among a cohort of United Kingdom steel foundry workers with special reference to cancers of the stomach and lung, 1946–90. Occup Environ Med. 1994;51(5):316–322
  33. Hayes RB, Lilienfeld AM, Snell LM. Mortality in chromium chemical production workers: a prospective study. Int J Epidemiol. 1979;8(4):365–374
  34. Horiguchi S, Morinaga K, Endo G. Epidemiological study of mortality from cancer among chromium platers. Asia Pac J Public Health. 1990;4(2–3):169–174
  35. Sorahan T, Burges DC, Waterhouse JA. A mortality study of nickel/chromium platers. Br J Ind Med. 1987;44(4):250–258
  36. Silverstein M, Mirer F, Kotelchuck D, Silverstein B, Bennett M. Mortality among workers in a die-casting and electroplating plant. Scand J Work Environ Health. 1981;7(Suppl. 4):156–165
  37. Hayes RB, Sheffet A, Spirtas R. Cancer mortality among a cohort of chromium pigment workers. Am J Ind Med. 1989;16(2):127–133
  38. Hara T, Hoshuyama T, Takahashi K, Delgermaa V, Sorahan T. Cancer risk in Japanese chromium platers, 1976–2003. Scand J Work Environ Health. 2009;
  39. Satoh K, Fukuda Y, Torii K, Katsuno N. Epidemiological study of workers engaged in the manufacture of chromium compounds. J Occup Med. 1981;23(12):835–838
  40. Moulin JJ, Wild P, Haguenoer JM, Faucon D, De Gaudemaris R, Mur JM, et al. A mortality study among mild steel and stainless steel welders. Br J Ind Med. 1993;50(3):234–243
  41. Iaia TE, Bartoli D, Calzoni P, Comba P, De Santis M, Dini F, et al. A cohort mortality study of leather tanners in Tuscany, Italy. Am J Ind Med. 2006;49(6):452–459
  42. Cole P, Rodu B. Epidemiologic studies of chrome and cancer mortality: a series of meta-analyses. Regul Toxicol Pharmacol. 2005;43(3):225–231
  43. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55(2):74–108
  44. IARC-WHO . GLOBOCAN 2002 database: cancer incidence, mortality and prevalence worldwide, estimates for the year 2002. 2002;Available from: http://www-dep.iarc.fr
  45. La Vecchia C, Tavani A, Franceschi S, Levi F, Corrao G, Negri E. Epidemiology and prevention of oral cancer. Oral Oncol. 1997;33(5):302–312
  46. Montanaro F, Ceppi M, Demers PA, Puntoni R, Bonassi S. Mortality in a cohort of tannery workers. Occup Environ Med. 1997;54(8):588–591
  47. Arrighi HM, Hertz-Picciotto I. The evolving concept of the healthy worker survivor effect. Epidemiology. 1994;5(2):189–196
  48. Checkoway H, Pearce N, Kriebel D. Research methods in occupational epidemiology. 2nd ed.. New York, NY: Oxford University Press; 2004;
  49. Choi BC. Definition, sources, magnitude, effect modifiers, and strategies of reduction of the healthy worker effect. J Occup Med. 1992;34(10):979–988
  50. McMichael AJ. Standardized mortality ratios and the “healthy worker effect”: scratching beneath the surface. J Occup Med. 1976;18(3):165–168
  51. Wen CP, Tsai SP, Gibson RL. Anatomy of the healthy worker effect: a critical review. J Occup Med. 1983;25(4):283–289
  52. US Environmental Protection Agency . Rapid assessment of exposure to particulate emissions from surface contamination sites. EPA/600-8-85002. Washington, DC: Office of Health and Environmental Assessment, United States Environmental Protection Agency; 1985;
  53. Marano DE, Boice JD, Fryzek JP, Morrison JA, Sadler CJ, McLaughlin JK. Exposure assessment for a large epidemiological study of aircraft manufacturing workers. Appl Occup Environ Hyg. 2000;15(8):644–656
  54. Proctor DM, Panko JP, Liebig EW, Scott PK, Mundt KA, Buczynski MA, et al. Workplace airborne hexavalent chromium concentrations for the Painesville, Ohio, chromate production plant (1943–1971). Appl Occup Environ Hyg. 2003;18(6):430–449
  55. ATSDR . Toxicological profile for chromium. Draft. Atlanta, GA: Agency for Toxic Substances and Disease Registry. US. Department of Health and Human Services; 2008;
  56. Sabty-Daily RA, Harris PA, Hinds WC, Froines JR. Size distribution and speciation of chromium in paint spray aerosol at an aerospace facility. Ann Occup Hyg. 2005;49(1):47–59
  57. Langard S, Andersen A, Ravnestad J. Incidence of cancer among ferrochromium and ferrosilicon workers: an extended observation period. Br J Ind Med. 1990;47(1):14–19
  58. Pippard EC, Acheson ED, Winter PD. Mortality of tanners. Br J Ind Med. 1985;42(4):285–287
  59. Simonato L, Fletcher AC, Andersen A, Anderson K, Becker N, Chang-Claude J, et al. A historical prospective study of European stainless steel, mild steel, and shipyard welders. Br J Ind Med. 1991;48(3):145–154
  60. Sorahan T, Harrington JM. Lung cancer in Yorkshire chrome platers, 1972–97. Occup Environ Med. 2000;57(6):385–389

PII: S1877-7821(10)00053-6

doi: 10.1016/j.canep.2010.03.013

Cancer Epidemiology
Volume 34, Issue 4 , Pages 388-399 , August 2010

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