Cancer Epidemiology
Volume 34, Issue 2 , Pages 150-156, April 2010

Genetic polymorphism of epidermal growth factor 61A>G and cancer risk: A meta-analysis

  • Yan-Mei Zhang

      Affiliations

    • Department of Internal Medicine, the Second Hospital of Anhui Medical University, 678 Furong Road, Hefei 230601, China
    • These authors have contributed equally to this work.
    • Corresponding Author InformationCorresponding author. Tel.: +86 15156086973; fax: +86 05513869627.
    • ,
  • Chao Cao

      Affiliations

    • Department of Respiratory Medicine, the Affiliated Hospital of School of Medicine, Ningbo University, Ningbo 315020, China
    • These authors have contributed equally to this work.
    • ,
  • Kun Liang

      Affiliations

    • Department of Basic Medicine, College of Basic Medicine, Anhui Medical University, Hefei 230601, China

Accepted 9 February 2010. published online 25 February 2010.

Abstract 

Background: Numerous studies have investigated the risk of cancer associated with the polymorphism of epidermal growth factor (EGF) 61A>G, but the results have been inconsistent. We performed this meta-analysis to drive a more precise estimation of association between this polymorphism and risk of cancer. Methods: Electronic searches of PubMed and EMBASE were conducted to select studies. Case-control studies containing available genotype frequencies of EGF 61A>G were chose, and Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. Results: 23 case-control studies including 5578 cases and 7306 controls were identified. This meta-analysis showed significant effect of EGF 61A>G on cancer risk (GG vs. AA: OR=1.34, 95%CI=1.05–1.72; GG vs. GA+AA: OR=1.23, 95%CI=1.03–1.47; GG+GA vs. AA: OR=1.18, 95%CI=1.02–1.38). In subgroup analysis, significant increased risk was found in gastric cancer and glioma in additive model (OR=1.54, 95%CI=1.13–2.12; OR=1.69, 95%CI=1.21–2.37) and in recessive model (OR=1.29, 95%CI=1.10–1.52; OR=1.54, 95%CI=1.16–2.04). Conclusion: This meta-analysis suggested that the EGF 61G allele is a risk factor of cancer, especially for gastric cancer and glioma.

Keywords: EGF, Polymorphism, Cancer, Meta-analysis

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PII: S1877-7821(10)00022-6

doi:10.1016/j.canep.2010.02.004

Cancer Epidemiology
Volume 34, Issue 2 , Pages 150-156, April 2010

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