Cancer Epidemiology
Volume 34, Issue 1 , Pages 62-65 , February 2010

Second cancers following the diagnosis of Merkel cell carcinoma: A nationwide cohort study

  • Virve Koljonen

      Affiliations

    • Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    • Corresponding Author InformationCorresponding author at: Department of Plastic Surgery, Töölö Hospital, P.O. Box 266, FI-00029 HUS, Finland. Tel.: +358 50 427 1983; fax: +358 9 471 87 217.
    • ,
  • Heli Kukko

      Affiliations

    • Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • Erkki Tukiainen

      Affiliations

    • Department of Plastic Surgery, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • Tom Böhling

      Affiliations

    • Department of Pathology, Helsinki University and HUSLAB, Helsinki, Finland
    • ,
  • Risto Sankila

      Affiliations

    • Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland
    • ,
  • Heikki Joensuu

      Affiliations

    • Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland
    • ,
  • Eero Pukkala

      Affiliations

    • Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland
    • School of Public Health, University of Tampere, Tampere, Finland

,Accepted 9 December 2009.

References 

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  2. Hodgson NC. Merkel cell carcinoma: changing incidence trends. J Surg Oncol. 2005;89(1):1–4
  3. Walsh NM. Primary neuroendocrine (Merkel cell) carcinoma of the skin: morphologic diversity and implications thereof. Hum Pathol. 2001;32(7):680–689
  4. Brenner B, Sulkes A, Rakowsky E, Feinmesser M, Yukelson A, Bar-Haim E, et al. Second neoplasms in patients with Merkel cell carcinoma. Cancer. 2001;91(7):1358–1362
  5. Ziprin P, Smith S, Salerno G, Rosin RD. Two cases of Merkel cell tumour arising in patients with chronic lymphocytic leukaemia. Br J Dermatol. 2000;142(3):525–528
  6. Sinclair N, Mireskandari K, Forbes J, Crow J. Merkel cell carcinoma of the eyelid in association with chronic lymphocytic leukaemia. Br J Ophthalmol. 2003;87(2):240
  7. Bedane C, Clavere P, Lavignac C, Labrousse F, Olivier JP, Bonnetbalnc JM. Neuroendocrine primary cutaneous carcinoma, Therapeutic aspects in 13 patients. Ann Dermatol Venereol. 1996;123(8):443–446
  8. Feng H, Shuda M, Chang Y, Moore PS. Clonal integration of a polyomavirus in human Merkel cell carcinoma. Science. 2008;319(5866):1096–1100
  9. Foulongne V, Kluger N, Dereure O, Brieu N, Guillot B, Segondy M. Merkel cell polyomavirus and Merkel cell carcinoma, France. Emerg Infect Dis. 2008;14(9):1491–1493
  10. Kassem A, Schopflin A, Diaz C, Weyers W, Stickeler E, Werner M, et al. Frequent detection of Merkel cell polyomavirus in human Merkel cell carcinomas and identification of a unique deletion in the VP1 gene. Cancer Res. 2008;68(13):5009–5013
  11. Becker JC, Houben R, Ugurel S, Trefzer U, Pfohler C, Schrama D. MC polyomavirus is frequently present in Merkel cell carcinoma of European patients. J Invest Dermatol. 2009;129(1):248–250
  12. Garneski KM, Warcola AH, Feng Q, Kiviat NB, Leonard JH, Nghiem P. Merkel cell polyomavirus is more frequently present in North American than Australian Merkel cell carcinoma tumors. J Invest Dermatol. 2009;129(1):246–248
  13. Sihto H, Kukko H, Koljonen V, Sankila R, Bohling T, Joensuu H. Clinical factors associated with Merkel cell polyomavirus infection in Merkel cell carcinoma. J Natl Cancer Inst. 2009;101(13):938–945
  14. Teppo L, Pukkala E, Lehtonen M. Data quality and quality control of a population-based cancer registry. Experience in Finland. Acta Oncol. 1994;33(4):365–369
  15. Teppo L, Pukkala E, Saxen E. Multiple cancer—an epidemiologic exercise in Finland. J Natl Cancer Inst. 1985;75(2):207–217
  16. Chuang SC, Scelo G, Tonita JM, Tamaro S, Jonasson JG, Kliewer EV, et al. Risk of second primary cancer among patients with head and neck cancers: a pooled analysis of 13 cancer registries. Int J Cancer. 2008;123(10):2390–2396
  17. Johannessen JV, Gould VE. Neuroendocrine skin carcinoma associated with calcitonin production: a Merkel cell carcinoma?. Hum Pathol. 1980;11(5 Suppl.):586–588
  18. Howard RA, Dores GM, Curtis RE, Anderson WF, Travis LB. Merkel cell carcinoma and multiple primary cancers. Cancer Epidemiol Biomarkers Prev. 2006;15(8):1545–1549
  19. Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Penas PF, et al. Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. J Am Acad Dermatol. 2008;58(3):375–381
  20. Allen PJ, Bowne WB, Jaques DP, Brennan MF, Busam K, Coit DG. Merkel cell carcinoma: prognosis and treatment of patients from a single institution. J Clin Oncol. 2005;23(10):2300–2309
  21. Medina-Franco H, Urist MM, Fiveash J, Heslin MJ, Bland KI, Beenken SW. Multimodality treatment of Merkel cell carcinoma: case series and literature review of 1024 cases. Ann Surg Oncol. 2001;8(3):204–208
  22. Dancey AL, Rayatt SS, Soon C, Ilchshyn A, Brown I, Srivastava S. Merkel cell carcinoma: a report of 34 cases and literature review. J Plast Reconstr Aesthet Surg. 2006;59(12):1294–1299
  23. Kassem A, Technau K, Kurz AK, Pantulu D, Loning M, Kayser G, et al. Merkel cell polyomavirus sequences are frequently detected in nonmelanoma skin cancer of immunosuppressed patients. Int J Cancer. 2009;125(2):356–361

PII: S1877-7821(09)00186-6

doi: 10.1016/j.canep.2009.12.007

Cancer Epidemiology
Volume 34, Issue 1 , Pages 62-65 , February 2010

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